Alkynyl-functionalised and linked bicyclo[1.1.1]pentanes of group 14.
نویسندگان
چکیده
We report the synthesis and properties of alkynyl-functionalised and -bridged bicyclo[1.1.1]pentane derivatives consisting of the heavier group 14 elements silicon and tin.
منابع مشابه
1,3-Bicyclo ACHTUNGTRENNUNG[1.1.1]pentanediyl: The Shortest Rigid Linear Connector of Phenylated Photochromic Units and a 1,5-Dimethoxy-9,10- di(phenylethynyl)anthracene Fluorophore
BicycloACHTUNGTRENNUNG[1.1.1]pentane and its derivatives are not only of theoretical interest, but have attracted particular attention of organic and physical-organic chemists as peculiar fragments in oligomers, liquid crystalline compounds, supramolecular aggregates and monolayers, as well as compounds for drug design, etc. 1,3-Disubstituted derivatives—bicycloACHTUNGTRENNUNG[1.1.1]pentanes wi...
متن کاملA practical metal-free homolytic aromatic alkylation protocol for the synthesis of 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid.
As a part of our ongoing synthetic quest to expand the frontiers of contemporary medicinal chemistry, we now report an expedient synthesis of a potentially useful bicyclo[1.1.1]pentane building block, 3-(pyrazin-2-yl)bicyclo[1.1.1]pentane-1-carboxylic acid. This report also showcases the application of this motif as a probe in a biological study.
متن کاملRhombellanic Crystals and Quasicrystals
Design of some crystal and quasicrystal networks, based on rhombellane tiling,is presented. [1,1,1]Propellane,is a synthesized organic molecule; its hydrogenated form, the bicyclo[1.1.1]pentane,may be represented by the complete bipartite graph K2,3 which is the smallest rhombellane. Topology of translational and radial structures involving rhombellanes is described in terms of vertex symbol, c...
متن کاملApplication of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
Replacement of the central, para-substituted fluorophenyl ring in the γ-secretase inhibitor 1 (BMS-708,163) with the bicyclo[1.1.1]pentane motif led to the discovery of compound 3, an equipotent enzyme inhibitor with significant improvements in passive permeability and aqueous solubility. The modified biopharmaceutical properties of 3 translated into excellent oral absorption characteristics (~...
متن کاملSynthesis of a chiral amino acid with bicyclo[1.1.1]pentane moiety and its incorporation into linear and cyclic antimicrobial peptides.
The synthesis of the lipophilic chiral amino acid 1 bearing the bicyclo[1.1.1]pentane moiety is described. Linear and cyclic hexapeptides of the type Arg-Arg-Xaa-Yaa-Arg-Phe containing 1 instead of one or two tryptophan residues are prepared by solid phase peptide synthesis and the antimicrobial and hemolytic activity of the peptides obtained are discussed.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 48 54 شماره
صفحات -
تاریخ انتشار 2012